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GameTime Picks

NFL · Matchup research

Arizona Cardinals at San Francisco 49ers

Sun, Sep 27, 4:05 PM ET · 2026 season

Schedule

Scheduled start: Sun, Sep 27, 4:05 PM ET

Game page →

The teams entering this game

Each team's own recorded finals. The two recent lists are not the same dates.

2026 before this game
1–1
2 recorded finals
Points per final
16.5–22.5
scored–allowed, n=2
2025 season
3–14
17 recorded finals · 20.9–28.7 per final

Last 5 recorded finals before this game · 1–4

  • L7–31vs Seattle SeahawksSep 20, 2026Game →
  • W26–14@ Los Angeles ChargersSep 13, 2026Game →
  • L20–37@ Los Angeles RamsJan 4, 2026
  • L14–37@ Cincinnati BengalsDec 28, 2025
  • L19–26vs Atlanta FalconsDec 21, 2025
2026 before this game
2–0
2 recorded finals
Points per final
31–10
scored–allowed, n=2
2025 season
13–6
19 recorded finals · 24.5–22.7 per final

Last 5 recorded finals before this game · 3–2

  • W35–13vs Miami DolphinsSep 20, 2026Game →
  • W27–7vs Los Angeles RamsSep 10, 2026Game →
  • L6–41@ Seattle SeahawksJan 17, 2026
  • W23–19@ Philadelphia EaglesJan 11, 2026
  • L3–13vs Seattle SeahawksJan 3, 2026

Recorded meetings before this game

Official finals between these teams, seasons 1999–2026 in GameTimePicks data (most recent 10 listed). Not an all-time series.

50 recorded meetings: Arizona Cardinals 22 · San Francisco 49ers 28

Most recent recorded meetings, newest first
DateSiteArizona CardinalsSan Francisco 49ersGame page
Nov 16, 2025at Arizona Cardinals2241
Sep 21, 2025at San Francisco 49ers1516
Jan 5, 2025at Arizona Cardinals4724
Oct 6, 2024at San Francisco 49ers2423
Dec 17, 2023at Arizona Cardinals2945
Oct 1, 2023at San Francisco 49ers1635
Jan 8, 2023at San Francisco 49ers1338
Nov 21, 2022Neutral site1038
Nov 7, 2021at San Francisco 49ers3117
Oct 10, 2021at Arizona Cardinals1710

Current GameTime forecast

Model output, not historical fact

GameTimePicks published a forecast for this game. It lives in the game report with its own reasoning, risk and status; nothing on this page changes it.

Open the NFL game report →

Players with a published range in that report: Bam Knight · Brock Purdy · Christian McCaffrey · Deebo Samuel Sr. · George Kittle · Jacoby Brissett · James Conner · Jeremiyah Love · Jordan James · Kaelon Black · Kendrick Bourne · Kyle Juszczyk · Mac Jones · Marvin Harrison Jr. · Michael Wilson · Mike Evans · Ricky Pearsall · Trey Benson · Trey McBride · Tyler Allgeier

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